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Melinda Sheffield-Moore

Melinda Sheffield-Moore

University of Texas Medical Branch

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Dr. Sheffield-Moore's research program is focused on the metabolic and molecular mechanisms behind the cachexia of cancer and the sarcopenia of aging.

In the past 14 years at UTMB, she has directed as PI or Co-I human clinical translational research projects in healthy and diseased populations employing a variety of clinical and molecular medicine based techniques to examine skeletal muscle protein metabolism and skeletal muscle microvascular blood flow.These projects have sought to identify the mechanisms and pathways responsible for skeletal muscle atrophy during cancer, aging, inactivity, bedrest/hospitalization, and trauma and burns.

Additionally, her research has also employed various clinical interventions to identify the mechanisms and pathways responsible for skeletal muscle hypertrophy including vasodilators, testosterone, amino acids and exercise. Her laboratory has been at the leading edge of novel in vivo techniques such as contrast-enhanced ultrasound, used to non-invasively measure skeletal muscle tissue perfusion in an effort to dissect the role of muscle perfusion in age-related muscle loss. Finally, she is studying the efficacy of nutrition and testosterone at preventing or reducing cancer-related muscle loss in patients with cervical or head and neck cancer.